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Question: All of the drug candidates listed below failed to make it to the market. Indicate point in the dr…

Question: All of the drug candidates listed below failed to make it to the market. Indicate point in the dr...

All of the drug candidates listed below failed to make it to the market. Indicate point in the drug discovery/development pipeline that the drug candidates probably failed. A cholesterol lowering drug candidate was found to lead to a serious rash in all patients tested. An anti-hypertension drug candidate was found to lower blood pressure in non-human primates but was only effective in humans at high doses. A cholesterol drug was determined to be too costly to produce in order to compete with existing drugs on the market. An anti-nausea drug was found to have a very short half-life due to rapid metabolism. An antidepressant drug candidate was found to cause severe stomach ulcers in adolescent patients. An analgesic drug candidate was found to have a therapeutic index of 1.2.

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