All of the drug candidates listed below failed to make it to the market. Indicate point in the drug discovery/development pipeline that the drug candidates probably failed. A cholesterol lowering drug candidate was found to lead to a serious rash in all patients tested. An anti-hypertension drug candidate was found to lower blood pressure in non-human primates but was only effective in humans at high doses. A cholesterol drug was determined to be too costly to produce in order to compete with existing drugs on the market. An anti-nausea drug was found to have a very short half-life due to rapid metabolism. An antidepressant drug candidate was found to cause severe stomach ulcers in adolescent patients. An analgesic drug candidate was found to have a therapeutic index of 1.2.