24/7 Study Help

Studykind Will Help You Write Your Essays and Term Papers

From initial topic to finished paper

Want answers to the assignment Below? 

For premier support Text or Whatsapp Ivanna at +1(478) 377-7377 

Question: Creatine (Cr) is made in the liver and kidneys and then transported to the muscles, where it serv…

Creatine (Cr) is made in the liver and kidneys and then
transported to the muscles, where it serves as a high energy
storage compound via phosphorylation by creatine kinase. Two forms
of this enzyme exist, mitochondrial and cytoplasmic. In
mitochondria there is net synthesis of creatine phosphate (CrP). In
the cytosol, the phosphate is transferred from CrP to ADP to supply
ATP to power the muscles. Table 3.2 of your G&G text lists ΔG˚́
for hydrolysis of creatine phosphate: -43.3 kJ/mol at 25°C.
creatine phosphate + H2O —-> creatine + Pi

a. Calculate the Keq́ for this hydrolysis.

c. In mouse muscle cells at 25°C, [Cr] is 10 mM, and [CrP] is 20
mM. What concentration of Pi would be needed to maintain this level
of phosphorylation by reversal of the hydrolysis reaction? Is this
concentration of Pi a reasonable expectation? Why?

d. Coupling ATP hydrolysis (ΔG˚́-35.7 kJ/mol at 25°C) to an
unfavorable reaction is often used to drive biochemical reactions.
Write the chemical equations for the CrP reverse hydrolysis and ATP
hydrolysis and add them together to give the coupled reaction. Then
calculate ΔG˚́for the coupled reaction. Is this reaction favorable?
Justify your answer.

e. Considering ΔǴin the muscle cells rather than under 1M
standard state conditions, what ratio of ATP/ADP would be needed
inside mitochondria to make the coupled reaction for CrP synthesis
produce the concentrations of Cr and CrP observed in mouse muscle?
Is this ratio reasonable? Why?

Essay Writing Service Ready to Help Online 24/7

Hire a professional just from $9.99

Click here

HOME TO CERTIFIED WRITERS

Why Place An Order With Us?

  • Certified Editors
  • 24/7 Customer Support
  • Profesional Research
  • Easy to Use System Interface
  • Student Friendly Pricing

Have a similar question?

Need a previously written solution for this question?

Services that we offer

Your Paper Is In Safe Hands

PLAGIRAISM FREE PAPERS

All papers we provide are well-researched, properly formatted and cited.

TOP QUALITY

All papers we provide are well-researched, properly formatted and cited.

HIGHLY SECURED

All papers we provide are well-researched, properly formatted and cited.

Related Assignments

Study more efficiently

Quickly get your essay from idea to final graft save time, money and effort.

Boost your grade

Get through your toughest problem and learn how to solve them from expert writers

Get on board with the best writers.

“All our writers are certified professionals, holding Masters Degrees and above.”

Our company has worked successfully in the field of academic assistance for over 11 years. We consistently upgrade our goals to improve the quality of service we provide and to maximize customer satisfaction. Success has driven us forward to an innovative concept. Our working experience, customer feedback, and market resources have brought about the creation of an exclusive online service:

Chat now
Powered by Studykind
Hello! Welcome to to our whatapp support.

We offer READY solutions, HIGH QUALITY PLAGIARISM FREE essays and term-papers.

We are online and ready to help.