*Help with GENETICS HW Questions*

1.) The following human family pedigree represent the
inheritance of Waardenburg syndrome, a congenital monogenic trait
characterized by deafness, fair skin, visual problems, and a white
forelock:

Questions to answer:

a. What is the mode of inheritance of Waardenburg syndrome?
Explain.

b. Is the trait autosomal or sex-linked? Why?

c. Is the trait dominant or recessive? Why?

d. Assume that the trait is monogenic and indicate the allelic
representation (specify the phenotype determined by each
allele/letter, i.e. affected or unaffected), and allelic
relationship (which allege is dominant, and which is recessive)

e. For each individual listed below, indicate the following
information:

i. Generation number- individual number = phenotype (affected or
Waardenburg vs unaffected) gender and 2 letter genotype (to
identify the different individuals in the pedigree, note that
generation and individual numbers: ex I. for the unaffected female
and its 2 letter genotype. Example: I. unaffected male, ?? (?? is
the appropriate 2 letter genotype)

ii. What can you say about the genotypes of all affected
individuals?

iii. What is the scientific name given to individual IV. 2 in
this pedigree? Why is the relevance of this specific
individual?

I. 1

I. 2

II. 1

II. 2

II. 3

II. 4

II. 5

III. 1

III. 2

III. 3

III. 5

III. 6

III. 7

III. 8

III. 9

III. 10

III. 13

IV. 1

IV. 2

IV. 3

IV. 5

IV. 6

IV. 7

IV. 8

IV. 11