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Question: Overview How do you study pathophysiology? You have observed a case, and you have read many artic…


How do you study pathophysiology? You have observed a case, and
you have read many articles on topics related to how our body
adapts to environmental toxins on a cellular level. Now you are
going to go deeper in your observations to build your report.


In at least 375 words, or 1.5 double-spaced pages, prepare a
case report that addresses the following:

Based on the case study provided, respond to the following

Identify and differentiate the symptoms from the signs in this

What is the personal and social history of our patient?

What is the family history?

What results do you expect to find in the tests ordered?

What are some complications the patient is suffering now?

In regard to the patient’s mother’s breast cancer:

What are the four mechanisms of cellular adaptation?

What is the general classification of neoplasms according to
their tissue of origin?

How would sickle cell anemia induce ischemia? What are the
differences between ischemia and necrosis?

What are the differences between sickle cell anemia and
leukemia? Compare their pathophysiology, symptoms, signs, and lab

All references must be cited using APA Style format.

Case Study:

Personal Information

Name: Mr. Peter Smith

Age: 45 years old

Gender: Male


Mr. Peter Smith came to the medical office complaining of
fatigue, asthenia, headaches, and generalized abdominal pain. Our
patient tells us that he has had a high fever, but he did not take
his temperature. The patient has had previous episodes of abdominal
pain and arthralgia. Also, he was diagnosed with sickle cell anemia
when he was a child. His father suffers from sickle cell anemia,
diabetes mellitus, and essential hypertension. Our patient’s mother
had a right radical mastectomy due to breast cancer a few years
ago, and she suffers from sickle cell anemia, like Mr. Smith and
his father. There is no other remarkable pathologic family

Mr. Smith drinks alcohol at least once per month and smoke
cigarettes. He has no history of drug addiction. He is allergic to
penicillin and iodine.

On physical we found:

Remarkable Signs on Physical Regions

Abdomen: Distended and painful on palpation, mostly on the left
upper quadrant. Splenomegaly.

SOMA: Joint pain

Remarkable Signs on Physical by Systems

Integumentary system: Yellowish skin and pale nail beds.
Superficial crater-like skin lesion on the right medial ankle area.
An erythematous area accompanied by edema, purulent secretion, and
heat surrounds the lesion.

Respiratory system: Tachypnea

Cardiovascular system: Tachycardia

Lab Tests

Complete blood count (CBC)

Hemoglobin electrophoresis

Abdominal ultrasound


Supporting Material

In order to understand Mr. Smith’s case, we need to investigate
the primary concepts of homeostasis at a cellular level and explore
specific conditions when homeostasis is not present. How does our
body adapt to environmental toxins? We will explore this question
by looking at specific outcomes when there are deviations from
homeostasis in three specific areas:

Cellular adaption and neoplasia

Infection, immunity, and inflammation

Hematological disorders

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