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Btuly Bookmarks Window Help 令见빼 C 30% C83 Sat 11:1 what can be concluded about the effectiveness of the enhancers associat Upgrade to macOS High e myGeneseo: Home hulu Amazon.com.. DDs& more () Facebook menus Cheg Tutors Cloud DropboxT Cus 2010 Enoy the itest technologie 을 session.masteringbiology.com refinements to your favorte Chapter 19 Tutorial Chapter 19 Question 14 – Case Study previous l 16 of 16 ream to ass gin Chapter 19 Question 14 – Case Study What does gene regulation have to do with being blond? Scientists discovered that the difference between blond and dark hair comes down in part to a single nucleotide difference in the DNA sequence lies more than 350,000 base pairs away from the gene it controls. On average, blonds transcnibe this gene less efficiently than difference in a distant enhancer make a blond? of an enhancer that Part A The human gene controlled by the enhancer is called KITL G, and it codes for a signaling protein that binds to a cell-surface receptor. The signaling pathway hair or biond phenotypes, including hair color. Using genetic engineering methods, scientists fused a copy of K -the activated by the KITLG protein controls many important mouse equivalent of human KITLG-and its core promoter to forms of the human enhancer associated with either dark DNAs were introduced into mouse embryos, and the amount of Kiti mRNA present in embryonic mouse skin cells was measured and compared to untreatod controls. The results are shown below. 2.0 18 1.6 1.2 1.0 Kiti with Blond Dark” promoter entancer en ar Source: CA Guenther et al 2014. Nature Geneics 46: 748 https sclence.org/topicpages/h/hair cellstohcs.html ntipl