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What is the standard error of the mean difference?What is the standard error of the mean difference?

by | Jun 19, 2022 | Questions & Answers

drugs t Show more Makers of generic drugs must show that they do not differ significantly from the reference drugs that they imitate. One aspect in which drugs might differ is their extent of absorption in the blood. Table 18.6 gives data taken from 20 healthy nonsmoking male subjects for one pair of drugs. This is a matched pairs design. Numbers 1 to 20 were assigned at random to the subjects. Subjects 1 to 10 received the generic drug first and Subjects 11 to 20 received the reference drug first. In all cases a washout period separated the two drugs so that the first had disappeared from the blood before the subject took the second. By randomizing the order we eliminate the order in which the drugs were administered from being confounded with the difference in the absorption in the blood. Subj Ref Generic 15 4108 1755 3 2526 1138 9 2779 1613 13 3852 2254 12 1833 1310 8 2463 2120 18 2059 1851 20 1709 1878 17 1829 1682 2 2594 2613 4 2344 2738 16 1864 2302 6 1022 1284 10 2256 3052 5 938 1287 7 1339 1930 14 1262 1964 11 1438 2549 1 1735 3340 19 1020 3050 1. What is the mean difference of the sample? round your answer to the nearest integer. Answer 2. What is the standard error of the mean difference? Round your answer to the nearest tenth. Answer 3. What are the assumptions one needs to check to conduct this type of test (you may choose more than one answer) A. no large outliers B. sample is representative C. equality variances D. sample size >30 E. p-value less than alpha 4. The appropriate hypotheses are A. H0: ? = 0 Ha: ? > 0. B. H0: ? = 0 Ha: ? < 0. C. H0: ? = 0 Ha: ? ? 0. 5. What is the value of the test statistic? Give your answer to three decimal places. Answer 6. How many degrees of freedom does the test statistic have? Answer 7. Do the drugs differ significantly in absorption? A. Yes the drugs differ significantly in absorption (P < 0.01). B. Yes the drugs differ significantly in absorption (0.01 < P < 0.05). C. No the drugs don’t differ significantly in absorption (0.05 < P < 0.1). D. No the drugs don’t differ significantly in absorption (P > 0.1). 8. The 95% confidence interval for the difference goes from ___ to ____. Give your answer to three decimal places. Answer 1 Answer 2 Show less

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